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Osteoarthritis (OA) is a chronic condition characterized by joint damage and inflammation1

OA IS THE MOST COMMON FORM OF ARTHRITIS, AFFECTING OVER 30 MILLION ADULTS IN THE UNITED STATES2

  • Common signs of osteoarthritis include joint pain, swelling, and stiffness3
  • Inflammation is a major risk factor associated with cartilage loss4

Treatment should aim to relieve both the inflammation and pain associated with OA.

DRAG TO SEE OA INFLAMMATION & PAIN

EXPERTS RECOMMEND NSAIDS AS A FIRST-LINE PHARMACOLOGIC TREATMENT OPTION IN OA5-7

American College of Rheumatology

Pharmacologic recommendations for the initial management of knee and hand OA include oral and topical NSAIDs5

Centers for Disease Control and Prevention

Recommends oral and topical NSAIDs as first-line pharmacologic treatment options for OA6

NSAIDS ARE EFFECTIVE SYMPTOMATIC OA THERAPIES8

NSAIDS RELIEVE THE INFLAMMATION AND PAIN ASSOCIATED WITH OA

  • NSAIDs inhibit the cyclooxygenase (COX-1 and COX-2) enzymes from producing prostaglandins which are mediators of inflammation and pain8-10
  • NSAIDs are also known to have an analgesic effect9-11
  • Without
    NSAIDs
  • With
    NSAIDs
  • COX-1 or COX-2 binds to arachidonic acid.
  • COX-1 and COX-2 are enzymes that convert arachidonic acid into prostaglandins.
  • This leads to the creation of prostaglandins, which mediate inflammation and pain.8-10
  • NSAIDs bind to COX-1 or COX-2 so it cannot bind to arachidonic acid.8-10
  • COX-1 or COX-2 cannot trigger prostaglandin creation. Prostaglandin-induced inflammation and pain is reduced.8-10

DRAG TO SEE HOW NSAIDs REDUCE INFLAMMATION & PAIN

For illustrative purposes only.

Choose the most appropriate treatment option for your OA patients

Things to keep in mind when considering opioids

Get the facts

Consider the need for gastroprotection with NSAID therapy

See the data

See if a topical could be a more appropriate choice for OA knee pain

Review the research

REFERENCES

  1. Osteoarthritis Symptoms. Arthritis Foundation website. https://www.arthritis.org/about-arthritis/types/osteoarthritis/symptoms.php. Accessed January 15, 2019.
  2. Osteoarthritis (OA). Centers for Disease Control and Prevention website. https://www.cdc.gov/arthritis/basics/osteoarthritis.htm. Accessed January 15, 2019.
  3. Goldring MB, Otero M. Inflammation in Osteoarthritis. Curr Opin Rheumatol. 2011;23(5):471-478.
  4. What Is Rheumatoid Arthritis? Arthritis Foundation website. https://www.arthritis.org/about-arthritis/types/rheumatoid-arthritis/what-is-rheumatoid-arthritis.php. Accessed January 25, 2019.
  5. Hochberg MC, Altman RD, April KT, et al; American College of Rheumatology. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res. 2012;64(4):465-474.
  6. Nonopioid treatments for chronic pain. Centers for Disease Control and Prevention website. https://www.cdc.gov/drugoverdose/pdf/nonopioid_treatments-a.pdf. Accessed January 15, 2019.
  7. McAlindon TE, Bannuru RR, Sullivan MC, et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage. 2014;22(3):363-388.
  8. Crofford LJ. Use of NSAIDs in treating patients with arthritis. Arthritis Res Ther. 2013;15(suppl 3):S2.
  9. VIMOVO (naproxen/esomeprazole magnesium) [prescribing information] Horizon.
  10. Ricciotti E, FitzGerald GA. Prostaglandins and Inflammation. Arterioscler Thromb Vasc Biol. 2011;31(5): 986-1000.
  11. Cashman JN. The mechanisms of action of NSAIDs in analgesia. Drugs. 1996;52(suppl 5):13-23.