Osteoarthritis (OA) is a chronic condition characterized by joint damage and inflammation1
OA IS THE MOST COMMON FORM OF ARTHRITIS, AFFECTING OVER 30 MILLION ADULTS IN THE UNITED STATES2
- Common signs of osteoarthritis include joint pain, swelling, and stiffness3
- Inflammation is a major risk factor associated with cartilage loss4
Treatment should aim to relieve both the inflammation and pain associated with OA.
DRAG TO SEE OA INFLAMMATION & PAIN
EXPERTS RECOMMEND NSAIDS AS A FIRST-LINE PHARMACOLOGIC TREATMENT OPTION IN OA5-7
Pharmacologic recommendations for the initial management of knee and hand OA include oral and topical NSAIDs5
Recommends oral and topical NSAIDs as first-line pharmacologic treatment options for OA6
NSAIDS ARE EFFECTIVE SYMPTOMATIC OA THERAPIES8
NSAIDS RELIEVE THE INFLAMMATION AND PAIN ASSOCIATED WITH OA
- NSAIDs inhibit the cyclooxygenase (COX-1 and COX-2) enzymes from producing prostaglandins which are mediators of inflammation and pain8-10
- NSAIDs are also known to have an analgesic effect9-11
DRAG TO SEE HOW NSAIDs REDUCE INFLAMMATION & PAIN
For illustrative purposes only.
- Osteoarthritis Symptoms. Arthritis Foundation website. https://www.arthritis.org/about-arthritis/types/osteoarthritis/symptoms.php. Accessed January 15, 2019.
- Osteoarthritis (OA). Centers for Disease Control and Prevention website. https://www.cdc.gov/arthritis/basics/osteoarthritis.htm. Accessed January 15, 2019.
- Goldring MB, Otero M. Inflammation in Osteoarthritis. Curr Opin Rheumatol. 2011;23(5):471-478.
- What Is Rheumatoid Arthritis? Arthritis Foundation website. https://www.arthritis.org/about-arthritis/types/rheumatoid-arthritis/what-is-rheumatoid-arthritis.php. Accessed January 25, 2019.
- Hochberg MC, Altman RD, April KT, et al; American College of Rheumatology. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res. 2012;64(4):465-474.
- Nonopioid treatments for chronic pain. Centers for Disease Control and Prevention website. https://www.cdc.gov/drugoverdose/pdf/nonopioid_treatments-a.pdf. Accessed January 15, 2019.
- McAlindon TE, Bannuru RR, Sullivan MC, et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage. 2014;22(3):363-388.
- Crofford LJ. Use of NSAIDs in treating patients with arthritis. Arthritis Res Ther. 2013;15(suppl 3):S2.
- VIMOVO (naproxen/esomeprazole magnesium) [prescribing information] Horizon.
- Ricciotti E, FitzGerald GA. Prostaglandins and Inflammation. Arterioscler Thromb Vasc Biol. 2011;31(5): 986-1000.
- Cashman JN. The mechanisms of action of NSAIDs in analgesia. Drugs. 1996;52(suppl 5):13-23.